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High doses of caffeine during puberty might impair maturation of the adrenal glands.



The consumption of energy drinks and high levels of dietary caffeine has increased in children and adolescents. Human and animal studies have shown that chronic intake of high doses of caffeine affects serum glucocorticoid levels. Given that glucocorticoids play a role in peripubertal organ growth and development, chronic high doses of caffeine during puberty might impair maturation of the adrenal glands.

Caffeine may induce an endocrine imbalance that disturbs the establishment of the hypothalamo–pituitary adrenal axis during puberty, thereby leading to abnormal stress responses.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566528/


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